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In a 2008 clinical trial published in the journal Metabolism , type 2 diabetics were divided randomly into two groups and given either Metformin or Berberine (500 mg 3x/day) for three months

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Metformin is negligibly bound to plasma proteins and is, therefore, less likely to interact with highly protein-bound drugs such as salicylates, sulfonamides, chloramphenicol, and probenecid, as compared to the sulfonylureas, which are extensively bound to serum proteins