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Discontinuation Rates Discontinuation rates due to adverse events in the Phase 2 trial were dose-dependent, ranging from approximately 6% in the 1 mg arm to 16% in the 12 mg arm

In a series of 20 patients with nevoid melanoma, the mortality and metastasis rate at 3 years was 37.5%

Urine composition, such as pH, excessive calcium, oxalates, or uric acid in the urine are associated with kidney stone risk

either those that inhibit haem-iron availability or bacterial acquisition pathways, or toxic haem/iron-mimicking compounds that gain entry to bacterial cells through existing uptake systems ( 5.1.1 Siderophore synthesis inhibitors One of the earliest antimicrobials used for tuberculosis treatment, para-aminosalicylic acid, inhibits synthesis of the bacterial siderophore, mycobactin (Ribeiro and Simes, 2019)