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Patients with these conditions should discuss their medical history with their healthcare providers before starting GLP-1 therapy

Stahel et al., 2019

The understanding that obesity is a polygenic disease is well-established, with leptin (LEP), leptin receptor (LEPR), melanocortin 4 receptor (MC4R), and proopiomelanocortin (POMC) being prominent contributors

The high cost of brand-name medications makes insurance coverage highly desirable, but many plans have restrictions, exclusions, or complex prior authorization requirements

A prolyl oligopeptidase inhibitor, KYP-2047, reduces -synuclein protein levels and aggregates in cellular and animal models of Parkinsons disease