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Activated cells synthesize and release a variety of cytokines and inflammatory mediators, as well as activate signaling pathways such as NF-B (Hailman et al., 1994), MAPK (Chang et al., 2019), toll-like receptors (TLRs) and STAT-1, which triggers the synthesis and release of cytokines and inflammatory mediators like interleukin-1 (IL-1), interleukin-6 (IL-6), tumor-necrosis factor- (TNF-

It seems to be on the rise in Japan among certain demographics as well, so it is not someone else's problem