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Adjusting Dosages and Monitoring the Transition Keep a close eye on how youre doing to make sure your switch to tirzepatide goes well, especially when adjusting doses

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Red-flag symptoms Severe or worsening symptoms need prompt medical attention

Nasal tissue in animals treated with dihydroergotamine mesylate daily at nasal cavity surface area exposures (in mg/mm2) that were equal to or less than those achieved in humans receiving the maximum recommended daily dose of 0.08 mg/kg/day showed mild mucosal irritation characterized by mucous cell and transitional cell hyperplasia and squamous cell metaplasia