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18 In healthy individuals, vaccination induced shifts in receptor autoantibodies involved in autonomic and vascular regulation

Potential contraindications include: Pregnant or breastfeeding women should not undergo Epithalon therapy, as there is insufficient research to confirm safety for mother and child

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Dark circles have two primary causes that are frequently conflated but require different active responses: vascular pooling in the blood vessels around the eye, which produces a bluish-purple discolouration most visible through thin skin in that area, and surface pigmentation from UV exposure, post-inflammatory marks, or accumulated melanin, which produces a brownish discolouration

So far, however, research has been limited to test-tube and animal studies