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In several cases, prescription medications to treat these conditions further depleted these levels and resulted in complications

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Researchers modified the original peptide structure to create longer-acting formulations with various strategies: liraglutide (once daily) uses fatty acid albumin-binding, dulaglutide (once weekly) employs an Fc-fusion approach, exenatide extended-release (Bydureon, once weekly) utilises microsphere technology, and semaglutide (once weekly) incorporates fatty acid modifications

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