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The major pathways implicated in controlling metabolism and nutrient intake include the hypothalamic system leptin-melanocortin [12, 13], the adrenergic [14], cannabinoid [15], dopaminergic [16], and opioidergic [17] systems in the hypothalamus and other brain regions

Together, these eight pathogenic mechanisms complete the T2D ominous octet [65, 66]

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The lesions are generally 2 to 5 mm in diameter and lenticular, oval, or irregular in shape