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Unal DO, Sel T

A better understanding of these physiological abnormalities could lead to the discovery of novel pathways for treatments of potentially many neurodevelopmental disorders and other neurological disorders involving abnormalities in these metabolic pathways

Beyond the traditional M1-M2 paradigm, current transcriptomic analyses reveal greater TAM diversity with seven main subtypes: interferon-primed TAMs (IFN-TAMs), immune regulatory TAMs (Reg-TAMs), inflammatory cytokine-enriched TAMs (Inflam-TAMs), lipid-associated TAMs (LA-TAMs), proangiogenic TAMs (Angio-TAMs), RTM-like TAMs (RTM-TAMs), and proliferating TAMs (Prolif-TAMs) ( Figure 6 ) (94)

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Western blot analysis further confirmed the significant reduction in placental CYP3A4 and ER protein expression from mice exposed to fullerenols (Fig