Activated JNK translocates to mitochondria and phosphorylates anti-apoptotic Bcl-2 family members (e.g., Bcl-2 phosphorylation at serine residues such as Ser70) leading to functional inactivation of Bcl-2/Bcl-xL, and promotes pro-apoptotic conformational changes and mitochondrial translocation of Bax (55, 56)
Yan Z, Nie Q, Liu J, Chen J, Liu Y, Lu Y, et al
Herein, we provides a narrative review based on previous literature that provides a quick overview of generation of ROS, associated diseases and their inhibition by antioxidants
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