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SIRT3 expression is downregulated in obese patients, and deletion of SIRT3 leads to increased mitochondrial oxidative stress, reduced energy expenditure and worsened glucose metabolism, resulting in accelerated obesity under a high-fat diet (HFD) feeding [25, 26]

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Some of these may have weak anticonvulsant activity, and at least one metabolite may be responsible for the hepatotoxicity reported