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Researchers are still untangling the exact contributions of each mechanism, but the current evidence points to three major factors working together

From the gut compartment, the dose first enters the liver where some of it is metabolized and conjugated, and the rest enters the general circulation from where it is taken up by liver and tissues or excreted in the urine

Biologisch betrachtet sieht das wie folgt aus: GLP-1 steigert die Insulinsekretion und hemmt die Glucagonfreisetzung

10.2337/db10-0128 Diabetes 33 HoltM

Clinical implication Clinicians are encouraged to perform comprehensive evaluations prior to prescribing GLP-1 RA therapy in patients with a history of pancreatic disorders or other pancreatitis risk factors