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Power calculations were conducted based on the approximation that the sample size for a MR study is the sample size for exposure on outcome divided by the r 2 for genetic proxies on exposure [38, 39]

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de Rey-Pailhade, who extracted it from yeast and named it philothion. However, its chemical structure as a tripeptide (gamma-glutamyl-cysteinyl-glycine) wasnt fully characterized until 1935 by Frederick Gowland Hopkins at Cambridge University

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