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STEP-1 Trial (Semaglutide 2.4 mg, N=1,961) The STEP-1 trial published in the New England Journal of Medicine reported that among participants receiving semaglutide 2.4 mg subcutaneously once weekly, nausea occurred in 44.2%, diarrhea in 29.7%, vomiting in 24.5%, and constipation in 24.1%, compared to 16.0%, 15.9%, 6.8%, and 11.1% with placebo, respectively [3]

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(2025) 3:E0119

This water-soluble tripeptide, made from the amino acids glycine, cysteine and glutamic acid, supports the cells in detoxification and helps protect them from damage caused by free radicals

However that gain comes in the form of water weight not extra body fat and theres a benefit there because the water is in the muscle cells, so it helps to hydrate your muscles, explains Kelly Jones, RD, a board-certified specialist in sports dietetics based in Philadelphia