High-intensity or prolonged physical activity may induce mechanical damage to muscle fibers, subsequently eliciting localized inflammatory responses (53)
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The inflammation-related damage factors released by cells after ferroptosis activate immune cells that further promote the progression of inflammation by impairing AA-mediated lipid metabolism, decreasing mitochondrial function, increasing oxidative stress, and reducing GPX4
This inflammation reaches the systemic level and, subsequently, the central nervous system (CNS), which can lead to oxidative stress and mitochondrial dysfunction, resulting in brain damage
My only question that Im not completely clear about is how much cooking or heating of vegetables or meat can occur before rendered these foods ineffective