Neurons that produce dopaminea chemical with pivotal involvement in motivation and pleasureproject to the nucleus accumbens, a midbrain structure important for experiencing reward, explains Patricia Sue Grigson, a neuroscientist and addiction researcher at Penn State College of Medicine
Intriguingly, one of these studies also showed that longer administrations can lead to a normalization of anxiety and a dissociable improvement in depression-like behavior 158 a pattern that resembles of the mechanisms of action of conventional antidepressants and that may be further suggestive of the activity of GLP-1RAs on the serotonin system 158
Reductions in heart failure 3 3
By reducing appetite and supporting weight loss, Wegovy may help interrupt this pattern
The most common reported side effects were gastrointestinal symptoms including nausea, diarrhea and vomiting, which occurred among 163 (34%) and 148 (31%) of patients in the intervention and control groups, respectively
