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Description

In addition to hepatotoxicity, VPA metabolites also cause teratogenicity by downregulating IGF2R (Insulin-like growth factor 2 receptor), RGS4 (Regulator of G protein signaling 4), COL6A3 (Collagen, type VI, alpha 3), EDNRB (Endothelin B receptor), and KLF6 (Krueppel-like factor 6) genes, as demonstrated in VPA-induced neural tube defects in a chick embryo prevalence model [89]

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