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Some of the most common causes include: Mental fatigue Anemia (iron deficiency) Chronic conditions, like heart disease , thyroid disease, sleep disorders, diabetes, or arthritis Medications, such as sedatives High use of alcohol or drugs Autoimmune conditions Malnutrition Chronic fatigue syndrome No matter the cause, fatigue impacts daily life

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For each participant, an individual mean baseline value was calculated as the arithmetic mean of the two measured baseline concentrations, and this mean value was subtracted from each concentration value measured on Days 12 and 67