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Combination therapy with ipilimumab and either nivolumab, pembrolizumab, and nivolumab-relatlimab-rmbw has been shown to increase overall survival compared to treating with ipilimumab alone

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The results imply that even residues not directly involved in the interaction may exhibit changes in their chemical environment if they are adjacent to residues crucial for the interaction or undergo conformational changes upon binding 39,40

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