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The reality: Injectables Still set the efficacy ceiling Strongest outcomes + label support Oral drugs Lower efficacy (~1113%) But expand the market significantly Key insight: This is not one oral category Oral semaglutide requires fasting + waiting Orforglipron taken anytime The winner may be the least inconvenient drug, not the most effective The Hidden Problem: Persistence This is the part almost no one talks about: Only ~24.5% of patients remain on therapy at 12 months ~20% switch therapies within a year After stopping: Weight regain 0.8 kg per month Let that sink in

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An FDA Advisory Committee is voting today and tomorrow on whether to recommend allowing 7 largely untested peptides to be made by compounding pharmacies and prescribed by physicians

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