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Any medication should be started at low doses with regular review of efficacy and tolerability

Methodological considerations and limitations of the regional summary The regional summary of neuroimaging findings ( Figure 2 ) indicates that GLP-1 RA effects have been reported in brain areas consistently identified in basic affective neuroscience research as responsive to the emotional content of visual stimuli, including the insula, amygdala, and orbitofrontal cortex (Frank et al., 2019

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Retatrutide is an investigational triple agonist targeting GIP, GLP-1, and glucagon receptors, currently under clinical evaluation for the management of obesity and type 2 diabetes