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The oral enhancer SNAC was critical for the successful oral delivery of semaglutide, as evidenced by the expected blood glucose-lowering effect in the SNAC-semaglutide group, while the control group without SNAC showed no effect

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Statistical analysis Statistical analyses were performed using Review Manager Software (Cochrane Collaboration, version 5.4.0)

In these five phase-3 trials, the efficacy of various tirzepatide doses were compared to a placebo, a GLP-1 receptor agonist (1mg semaglutide), and two long-acting insulin analogs