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In our study, we found that the increased A plaques firstly appeared in the cortex and hippocampus of earlier 8-week ethanol exposed APP/PS1 mice (in both 2BC and IP paradigms), and no A plaque was found even after 10 weeks ethanol exposure in WT mice, suggesting that chronic ethanol exposure did not directly result in A plaques but accelerate the A deposition

D-Ala substitution provided dual benefits: modest intrinsic potency enhancement (3-fold) plus protection against DPP-IV degradation

Alzheimers Dement (2014) 10(1 Suppl):S4754.10.1016/j.jalz.2013.12.009 73 IwaiTSawabeTTanimitsuKSuzukiMSasaki-HamadaSOkaJ

What makes peptides powerful is that they do not just manage symptoms

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