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In PCOS granulosa cells, elevated phosphorylation of the pro-apoptotic protein BAX, coupled with suppressed phosphorylation of the anti-apoptotic protein BCL-2, enhances mitochondrial pathway apoptosis, accelerating follicular atresia ( 3.6 Chronic low-grade inflammation Chronic low-grade inflammation have been identified as a central component in the pathogenesis of PCOS, rather than mere accompanying phenomena

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Glutathione is synthesized in all mammalian cells

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Together, these results mean that the metabolites of gut microbiota disturb regulation of joint FTN and homeostasis of iron, thereby may inducing iron overload that triggers ferroptosis and accelerate the development of OA