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It is clear that our understanding is still evolving

2), the ratio to the control treatment showed that the root growth of zir1 was affected similarly to that of the other glutathione mutants (Supplementary Figure S1)

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Moreover, in a xenograft mammary 4T1 tumor model, it has been demonstrated that the concurrent administration of BAPN and the enzyme-responsive drug (NQO1-SN38), designed to target breast tumors with the topoisomerase I inhibitor SN38, results in a cooperative reduction in tumor growth [100]

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