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Utilization of PBPK Modeling Approaches to Assess DDIs Caused by Mechanisms of Actions Evaluating the mechanism of action (eg, delayed gastric emptying, reduced fat mass and inflammation, and changes in GFR)-mediated DDIs of GLP-1 RAs and a dual GLP-1/GIP RA is often challenging to control for and clinical studies are costly

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Genetic ablation of MCT1 in T cells leads to impaired CD8 + T cell proliferation, a shift in energy metabolism toward oxidative phosphorylation, and a notable reduction in effector T cell accumulation within epididymal white adipose tissue (eWAT)

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