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doi:10.3389/fimmu.2013.00323

Research examining Retatrutide has focused on its modulation of food-intake signaling via GLP-1 and GIP receptor-mediated pathways alongside increased energy expenditure through glucagon receptor activation

A 2024 study published in Nature Scientific Reports surveying over 162,000 patients over an eight-year period reported a significant association of psychiatric symptoms in patients taking GLP-1 RAs, including a 195% risk of depression, 108% risk of anxiety, and 106% increased risk for suicidal behavior

It can be used for weight loss to reduce visceral fat, increases lean muscle mass, and aiding in better sleep quality