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conducted high-performance liquid chromatography (HPLC)tandem mass spectrometric (MS/MS) analysis on peptides derived from histones in MCF-7 cells and surprisingly discovered a mass shift identical to that induced by the addition of a lactyl group to lysine residues [3]
Tissues were obtained through the National Disease Research Interchange (Philadelphia, PA) with approval from the University of Pittsburgh Committee for Oversight of Research and Clinical Training Involving Decedents (CORID)
doi: 10.1016/j.numecd.2021.04.021 154
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