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All participants had overweight or obesity (BMI 27 kg/m) and pre-existing cardiovascular disease (CVD) but notably no diabetes

There is also evidence for mechanisms involving a reduction of neuroinflammation, an increase in synaptic functioning, as well as the restoration of brain pathways of insulin signaling that may lead to improved memory formation and therefore a positive effect in Alzheimers disease and Parkinsons disease 34

Stepping down from 2.4 mg to 1.7 mg, or even further to 1 mg, may resolve symptoms while maintaining some of the metabolic benefits of the medication

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