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Future research should further elucidate the regulatory roles of microbial metabolic networks (e.g., bile acids, SCFAs, and tryptophan metabolites) and leverage multi-omics technologies to refine personalized treatment strategies, thereby distinguishing therapeutic responses across PCOS subtypes and advancing precision medicine in reproductive endocrinology

Naunyn-Schmiedebergs Arch Pharmacol 392:13211330 Zatorski H, Salaga M, Zieliska M, Mokrowiecka A, Jacenik D, Krajewska WM, Maecka-Panas E, Fichna J (2021) Colonic inflammation induces changes in glucose levels through modulation of incretin system

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Comparative analyses between physiological testosterone replacement therapy and supraphysiological anabolic steroid abuse underscore the importance of dose and molecular structure in determining toxicity