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None of these endpoints has been validated against clinical outcomes for GLP-1R agonists specifically, and EVOKE is the cautionary case of how readily a biomarker shift and a clinical result can be conflated

Intermittent fasting works through a different set of mechanisms, shifting fuel utilization, improving insulin sensitivity, and triggering cellular cleanup processes

And so in 1999, I started working with liposome technologies early on because I thought that was superior technology at that point