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IGF-1 is synthesized primarily in the liver and various peripheral tissues in response to growth hormone signalling and exerts its biological effects through binding to the IGF-1 receptor, a transmembrane tyrosine kinase receptor

10.1016/j.jplph.2007.10.015 60 MeyerA

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Goal: Studied for telomerase activation, telomere maintenance and circadian/melatonin regulation effects reported mostly in older Russian and preclinical work, not established in humans [5] [6]