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The breakdown of oral glutathione in the gut is driven partly by the enzyme gamma-glutamyltransferase, which is why a conventional tablet raises blood glutathione only slightly (Buonocore et al., Oxidative Medicine and Cellular Longevity 2016, PMID 26649136)

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TCM formulations reshape the intestinal microbial community by increasing the abundance of SCFA-producing bacteria, such as those within the Bacteroidetes phylum, thereby elevating acetate, propionate, and butyrate levels (92, 93)