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When looking at the percentage of participants that dropped out of the trial due to adverse effects, 2-6% of patients in the cagrilintide group discontinued treatment early while 7% of the participants receiving liraglutide discontinued treatment early, These findings were in comparison to only 3% of test subjects from the placebo group that discontinued treatment due to adverse events [1]

IECs turn over completely every three to five days, making them highly dependent on efficient growth factor signaling and adequate ECM scaffolding

Because the concentration changes

It's also possible that GLP- 1 affects cells indirectly