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The administration of the gamma subtype of peroxisome proliferator-activated receptors (PPAR) ligands has been demonstrated to reduce the production of inflammatory cytokines, such as IL-1 and TNF-, as well as inhibit the proliferation of inflammatory cells and the expression of specific adhesion molecules (305)

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Among them, the most severe and clinically significant manifestations are pulmonary fat embolism (PFE), cerebral fat embolism (CFE), and vision loss due to fat embolism

All concern the failure to validate processes for products purporting to be sterile