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Mechanisms of beta-cell dedifferentiation in diabetes: recent findings and future research directions

This process involves two major human proteases: the TMPRSS2 in plasma membrane and cathepsin-L (CTSL) in the endo-lysosome 74

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It is known that NAD+ metabolism comprises multiple precursors, production routes, recycling pathways, and a myriad of consuming enzymes

Correcting low levels of NAD+ may slow or reverse the aging process and prevent problems like metabolic disease, brain degenerative disease, mental illness and cancer