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Third, clinical efforts should include establishing multicenter FRDA biobanks to validate associations between ferroptosis biomarkers (such as ACSL4 and mitochondrial iron content) and clinical measures including SARA ataxia scores and left ventricular ejection fraction, and conducting combination trials of ferroptosis inhibitors with ironsulfur cluster metabolism regulators to evaluate synergistic improvement in neurologic and cardiac function

It's also not recommended for pregnant women, those with a history of pancreatitis in some cases, and individuals with severe gastrointestinal disease

doi: 10.3389/fnagi.2020.614410 288 RajasekaranA.VenkatasubramanianG.BerkM.DebnathM

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