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In the last decade, several epigenetic mechanisms activated by IU hypoxia have been proposed to regulate the postnatal BBB permeability

Another mechanism by which the endo/lysosomal compartment can influence APAP-induced hepatotoxicity is through the clearance of damaged mitochondria in a process also called mitophagy, consisting in the degradation of dysfunctional mitochondria by lysosomal proteases upon fusion of the autophagosomes-containing mitochondria with lysosomes, which is discussed in the next section

Single use