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the extent of this brain penetration, however, is under debate and has been suggested to cover only the hypothalamus and hindbrain (140) or extend to many other populations including those found deep in the brain, for example in the hippocampus or NAc (27, 141, 142)

Some scientists like professor Charles Brenner are outspoken Sinclair critics

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Comparable positive effects on glutamate homeostasis via EAAT2 modulation have been shown in experimental models of stroke and various neurodegenerative disorders, underscoring the potential of NAC to restore glutamate equilibrium [5]