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This off-target binding is the likely contributor to its cortisol and ACTH co-secretion, as it stimulates the hypothalamic-pituitary-adrenal axis in addition to the GH axis

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The patient is carefully examined by a plastic surgeon at the first visit

Allergic Fungal Rhinosinusitis Adults and Pediatric Subjects 6 Years of Age and Older with AFRS A total of 62 adult and pediatric subjects 6 years of age and older with allergic fungal rhinosinusitis (AFRS) were evaluated in a randomized, double-blind, parallel-group, placebo-controlled trial (AIMS) with a 52-week treatment period [see Clinical Studies (14.9)]