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Although standard therapeutic modalities, including surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy, have improved, their clinical efficacy is often compromised by drug resistance, tumor microenvironment remodeling and immune evasion (2)

Topiramate is frequently used as a preventative measure for migraines, but there is currently little empirical data to support its efficacy through pathways related to neurogenic inflammation and oxidative stress

SOD2 knockout or null mutations cause growth inhibition on respiratory carbon sources in addition to decreased post-diauxic lifespan

Retrieved from Mozaffarian, D., Agarwal, M., Aggarwal, M., et al