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In 1994, a combination of dimethylfumarate and three salts of monoethylfumarate, Fumaderm, was approved in Germany for the treatment of psoriasis (Dunn 2013)

It also serves as a substrate for various antioxidant enzymes, including glutathione peroxidase and glutathione reductase, which further amplify its protective effects

While magnesium is essential for many bodily functions including muscle and nerve function, blood sugar regulation, and energy production its direct role in weight or fat loss is not strongly supported by research, says Narang

However, none of these mechanisms trigger GLP-1 secretion