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However, there have been very few serious side effects found, and these medications are considered safe for both short-term and long-term use

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Furthermore, a new orally bioavailable GLP-1RA, oral hypoglycemic peptide 2 (OHP2), can confer protective effects on diabetic cardiomyopathy through rescuing cardiac lipotoxicity by inhibiting Rho (the small GTPase) kinase (ROCK)/PPAR pathway [89, 90] (Figure 1)

In severe cases, dehydration or hypoglycemia (especially if used with certain drugs like insulin or sulfonylureas) can occur

Even though they need to be taken forever and are coded by the FDA as "forever drugs," intended to be taken for life, most people are off of them very soon