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There is no standardized cycle recognized by regulatory agencies

It enhanced IL-10 secretion, inhibited M1 macrophage polarization, and preserved tight junction proteins (ZO-1 and occludin), thereby maintaining barrier integrity

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conversely, SLC7A11 downregulation lead to ferroptosis (Liu et al., 2020

However, in advanced PD, excessive autophagy causes lysosomal membrane permeabilization (LMP), releasing cathepsins that activate caspasesa balance shift between apoptosis and autophagy [25,26]