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Blood glucose levels rise as the result of a combination of glucose-sparing and diabetogenic effects

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Addition of the sulfonate moiety to the molecule of a parent compound or most often to the molecule of its metabolite originating in the oxidative phase of drug metabolism leads to formation of a watersoluble compound which is then easily eliminated from the body

Factors such as individual metabolism, dosage, and whether the medication is taken with or without food can influence when symptoms appear

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