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Any perceived weight loss benefits likely stem from correcting an underlying deficiency that was causing fatigue, rather than from any inherent fat-burning mechanism

Unlike the hormonal approach of a GLP-1, phentermine acts directly on the central nervous system

Retatrutide appears to have a similar safety profile to other GLP-1 medications: No increased risk of pancreatitis in trials so far No hepatotoxicity signals (liver damage) No cases of ketoacidosis Serious adverse events were rare (2.5% of participants) The trials are ongoing, so we'll learn more about long-term safety

As of January 2025, 1,331 cases are pending in the GLP-1 RAs MDL, an increase of 31 since December 2024

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