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Copper accumulates in the senile plaque where it is tightly bound to Abeta ( In vitro , the Abeta-Cu 2+ complex, in the presence of a reducing agent, reduces oxygen to produce H 2 O 2 , and this involves recycling copper from Cu 2+ to Cu 1+ and back to Cu 2+ along with the oxidation of the reducing agent ( 2+

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In addition to its antioxidant function, GSH contributes to detoxification through its role in conjugation reactions catalyzed by glutathione S-transferases (GSTs), thereby preventing the accumulation of neurotoxic metabolites and supporting neuronal integrity

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