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doi: 10.1089/ars.2009.2832

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Another review noted that a daily dose of 400 milligrams of riboflavin led to a 50% decrease in migraine attacks for more than half of the study participants

Larger, longer-term studies are needed to establish durability and optimal dosing

The exclusion criteria were: females who were pregnant or experiencing a menstrual period, type 2 diabetes treated using an insulin regimen, malignancy, hematopathy, active tuberculosis, peptic ulcer with gastric bleeding, binge-eating disorder, psychiatric disease, congestive heart failure, clinically relevant renal or hepatic insufficiency, unstable coronary artery disease, cancer or a history of cancer