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With proven benefits for skin health, joint support, bone strength, and muscle recovery, they are increasingly being embraced by consumers looking for natural and functional solutions

They also act on the appetite centers in the brain, significantly reducing hunger and what is often called food noise. The dual-action drug tirzepatide works on both GLP-1 and GIP receptors, often leading to even greater efficacy

UK Availability At present, retatrutide is not approved for prescription or retail use in the UK

Supplementary Table S1 provided the main characteristics of included clinical trial and case-report studies which investigated the effect of nutrient supplements on migraine

doi:10.1186/s12933-025-02607-w 5