Side effects are most common during the first four weeks of taking the medication
Oxyntomodulin, a gut-derived peptide hormone, activates both the GLP-1R and the GCGR, although, with reduced affinity compared to GLP-1 and glucagon, respectively
Cardiovascular endpoints (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) were compared in those taking semaglutide versus placebo after a mean follow-up of 39.8 months, and the drug intervention was found to be superior to placebo
The standard recommended approach for such peptides is to perform initial reconstitution in acetic acid water to produce a clear stock solution, then store the stock solution (if multi-use storage is required) by adding bacteriostatic water or PBS for further dilution
They've written down the process